DOFETILIDE ASSOCIATED QT PROLONGATION: ACTUAL VERSUS IDEAL BODY WEIGHT TO CALCULATE DOSING

Actual versus ideal body weight for acute kidney injury diagnosis and classification in critically Ill patients

BACKGROUND In the current acute kidney injury (AKI) definition, the urine output (UO) criterion does not specify which body weights (BW), i.e. actual (ABW) versus ideal (IBW), should be used to diagnose and stage AKI, leading to heterogeneity across research studies. METHODS This is a single center, retrospective, observational study conducted at a tertiary referral hospital. All adult patien...

QT prolongation due to roxithromycin.

Roxithromycin and other macrolide antimicrobials are widely used for a broad variety of infections such as upper respiratory tract infection and community acquired pneumonia. Prolongation of the QT interval, torsade de pointes polymorphic ventricular tachycardia, and sudden death are well described but little known adverse reactions common to all macrolides. We report the case of a 72 year old ...

Medicines and QT Prolongation

Associations between trait emotional intelligence, actual–ideal weight discrepancy, and positive body image

This study examined associations between trait emotional intelligence (trait EI) and two measures of body image, namely actual–ideal weight discrepancy and body appreciation. A total of 108 women completed the Photographic Figure Rating Scale, the Body Appreciation Scale, the Trait Emotional Intelligence Questionnaire, the Sociocultural Attitudes Toward Appearance Questionnaire-3, and provided ...

Drug induced QT prolongation.

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...